On GetThere you are able to save your passport information (and receive reminders when this is due to expire), as well as any visa information. North American travellers can also save a TSA Redress Number into their traveller profile if they have one.
Under the flight preference section you can choose your home airport as well as seating and special meal preferences (for religious or dietary requirements).
For hotels, you can choose to save any special requirements from a select list (room on a high floor, room away from elevator etc.)
If you have a rail integration built into your travel portal, you can select your home station and the traveller’s age.
For car hire, you can select the type of car as well as transmission, and you can also choose to save any special requirements from a select list (e.g. luggage rack, 4 doors etc.)